Start by talking with your healthcare provider

You should not receive ZUSDURI if you have a hole or tear (perforation) of your bladder or if you have had an allergic reaction to mitomycin or to any of the ingredients in ZUSDURI.

Before receiving ZUSDURI, tell your healthcare provider about all of your medical conditions, including if you have kidney problems, are pregnant, or plan to become pregnant. ZUSDURI can harm your unborn baby. You should not become pregnant during treatment with ZUSDURI. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with ZUSDURI.

During treatment with ZUSDURI, your healthcare provider may tell you to take additional medicines or change how you take your current medicines. Ask your healthcare provider if you have any questions.

See additional IMPORTANT SAFETY INFORMATION below.

What to expect during treatment

Teal and blue calendar icon showing "6 WEEKS".

6 doses in total

Given once a week for 6 weeks
It is important that you receive all 6 doses of ZUSDURI according to your healthcare provider's instructions

Icon of a human bladder filled with liquid, showing a tube inserted and liquid splashing.

Delivered directly in the bladder

Your healthcare provider will give you ZUSDURI through a thin, flexible tube called a urinary catheter. The catheter will be inserted through your urethra and into your bladder. This method of delivering medicine is called intravesical therapy (IVT)
The process generally includes ~20 minutes to prepare ZUSDURI for administration, ~10 minutes to administer, and ~15 minutes before the catheter is removed

A teal circle with a diagonal line through it, indicating "no" or "prohibited," overlays a dark gray circular arrow.

With ZUSDURI, there's no need to hold in your urine or rotate positions to ensure the tumors are exposed to the medicine

An icon shows a person wearing a stethoscope, standing next to an open doorway.

ZUSDURI is typically given in a doctor's office or an outpatient clinic. You and your healthcare provider should talk about your particular case and what to expect
There's no need for general anesthesia or surgery and patients go home the same day

Lacey, a ZUSDURI patient, with reddish-brown hair and glasses, is shown speaking to someone.

Lacey is a ZUSDURI patient.

What to expect after treatment

After receiving ZUSDURI, your urine color may change to a violet to blue color:

Avoid contact between your skin and urine for at least 24 hours
To urinate, males and females should sit on the toilet and flush it several times after using it
After going to the bathroom, wash your hands, your inner thighs, and genital area well with soap and water
Clothing that comes in contact with urine should be washed right away and washed separately from other clothing

Some patients taking ZUSDURI may experience side effects. The most common ones include:

Increased blood creatinine levels
Increased blood potassium levels
Trouble with urination
Decreased red blood cell counts

Increase in certain blood liver tests
Increased or decreased white blood cell counts
Urinary tract infection
Blood in your urine

It's important to receive all 6 doses of ZUSDURI.
If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment

APPROVED USE FOR ZUSDURI

ZUSDURI (mitomycin) for intravesical solution is a prescription medicine used to treat adults with a type of cancer of the lining of the bladder called low-grade intermediate-risk non-muscle invasive bladder cancer (LG-IR-NMIBC) after you have previously received bladder surgery to remove tumor and it did not work or is no longer working.

IMPORTANT SAFETY INFORMATION

You should not receive ZUSDURI if you have a hole or tear (perforation) of your bladder or if you have had an allergic reaction to mitomycin or to any of the ingredients in ZUSDURI.

Before receiving ZUSDURI, tell your healthcare provider about all of your medical conditions, including if you:

have kidney problems
are pregnant or plan to become pregnant. ZUSDURI can harm your unborn baby. You should not become pregnant during treatment with ZUSDURI. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with ZUSDURI.
Females who are able to become pregnant: You should use effective birth control (contraception) during treatment with ZUSDURI and for 6 months after the last dose.
Males being treated with ZUSDURI: You should use effective birth control (contraception) during treatment with ZUSDURI and for 3 months after the last dose.
are breastfeeding or plan to breastfeed. It is not known if ZUSDURI passes into your breast milk. Do not breastfeed during treatment with ZUSDURI and for 1 week after the last dose.

How will I receive ZUSDURI?

You will receive your ZUSDURI dose from your healthcare provider 1 time a week for 6 weeks into your bladder through a tube called a urinary catheter. It is important that you receive all 6 doses of ZUSDURI according to your healthcare provider's instructions.

If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment.

During treatment with ZUSDURI, your healthcare provider may tell you to take additional medicines or change how you take your current medicines.

After receiving ZUSDURI:

ZUSDURI may cause your urine color to change to a violet to blue color. Avoid contact between your skin and urine for at least 24 hours.

To urinate, males and females should sit on a toilet and flush the toilet several times after you use it. After going to the bathroom, wash your hands, your inner thighs, and genital area well with soap and water.

Clothing that comes in contact with urine should be washed right away and washed separately from other clothing.

The most common side effects of ZUSDURI include: increased blood creatinine levels, increased blood potassium levels, trouble with urination, decreased red blood cell counts, increase in certain blood liver tests, increased or decreased white blood cell counts, urinary tract infection, blood in your urine.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to UroGen Pharma at 1-855-987-6436.

What to expect when receiving treatment with ZUSDURI